Job Description

Title: Postdoctoral Associate, Human Hepatic Models and Metabolism Studies
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours
Start: May
Overview: We are loo king for a highly motivated Postdoctoral Associate to join a lab focused on discovering novel therapeutics. This interdisciplinary program develops advanced in vitro models of hematopoietic and immune system function such as conducting research at the intersection of microphysiological systems (Organs-on-Chips) and immunology. The role emphasizes modeling hematopoietic stem and progenitor cell biology and immune cell development in relevant microenvironments while integrating immune readouts with multi-system platforms to study host responses and therapeutic modulation.

• Design and conduct experimental studies investigating hematopoietic stem and progenitor cell biology and immune cell development using advanced in vitro systems
• Establish and maintain multicellular cultures incorporating hematopoietic, stromal, and vascular components
• Perform and optimize assays to characterize immune cell populations, differentiation trajectories, and functional responses
• Apply quantitative techniques including flow cytometry, molecular assays, and functional immune assays to analyze experimental outcomes
• Contribute to development and refinement of experimental workflows to enhance reproducibility and robustness
• Collaborate with multidisciplinary teams to integrate immune-related findings with complementary biological and engineering systems
• Maintain accurate and detailed documentation of experimental procedures and results
• Analyze and interpret data, and contribute to preparation of manuscripts, reports, and grant applications
• Mentor trainees and assist in training of laboratory personnel as needed

Requirements:

• Ph.D. in Immunology, Hematology, Stem Cell Biology, Biomedical Engineering, or a related field
• Experience working with hematopoietic stem and progenitor cells and/or immune cell populations
• Strong background in cell culture and immune characterization techniques
• Demonstrated ability to design and execute complex biological experiments
• Ability to work independently and collaboratively in a multidisciplinary research environment
• Strong written and verbal communication skills

Preferred:

• Experience with in vitro hematopoietic or immune system models, including Organs-on-Chips
• Familiarity with flow cytometry, immunophenotyping, and multiparametric data analysis
• Experience with functional immune assays or host-response studies
• Experience working in interdisciplinary teams integrating biology and engineering

#M3
Ref: #558-Scientific

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System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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